The viruses in the genus Antivirus infect swine, resulting in an onset of African swine fever. The name of this family and genus is derived from the English language acronym: African swine fever and related viruses. Only a single species has been described to date for this genus. This virus is the only known arthropod-borne DNA viruses. It is enveloped and has a double-stranded DNA genome. African swine fever virus exhibits some similarities in genome structure and replication strategies to the poxviruses and phycodnaviruses but has a different visual structure from poxviruses and several other properties that distinguish it from the latter.
- Attachment of the viral proteins to host receptors mediates endometriosis of the virus into the host cell.
- Fusion with the endocrine vesicle membrane occurs; the DNA genome is released into the cytoplasm.
- Transcription of early viral genes; replication of the DNA genome in the cytoplasm begins about 6 hours post-infection.
- Following DNA replication, late viral genes are transcribed including structural proteins.
- Assembly of new virions occurs in cytoplasmic viral factories. Cytoplasmic reticulum cistern is recruited and transformed to give rise to precursor viral membranes, which represent the first identifiable viral structures. Viral membranes become tetrahedral particles by the gradual assembly of the outer caps-id layer formed by protein p72. At the same time, the matrix shell is formed underneath the viral envelope and the viral DNA and polynucleotides are packaged and condensed.
- Visions migrate to the plasma membrane on microtubules and bud.
Antivirus, any virus belonging to the family Asfarviridae. This family consists of one genus, Antivirus, which contains the African swine fever virus. Retroviruses have enveloped virions (virus particles) that are approximately 175–215 mm (1 NM
= 10−9 metro) in diameter. A tetrahedral caps-id (the protein shell surrounding the viral nucleic acids) contains linear double-stranded DNA.
The African swine fever virus is believed to circulate between soft-bodied ticks (Ornithologist) and pigs, specifically wild pigs (Sun’s scrota), warthogs (Pharmacopoeias arthroscopic), and bush pigs (Hippopotamus porous). The virus is found primarily in sub-Saharan Africa.
he virus can be grown in cell culture, but psychopathic effects may be absent. Hydrophilic, intracytoplasmic inclusion bodies may be visible in biopsies or post remote material. Replication is cytoplasmic and the virions mature by budding from the plasma membrane.
The viruses in this family infect domestic pigs and their relatives. The natural hosts are warthogs (Pharmacopoeias hurricanes), bush pigs (Hippopotamus porous), and teargas ticks (Ornithologist species). Young warthogs when infected develop high viragoes and are infectious to ticks. Older warthogs are generally immune to infection. The virus can replicate within the ticks. Trans-distal, transovarial, and sexual spread within the ticks occur.
During infection, the virions multiply in erythrocytes, endothelial cells, and leukocytes and not in the epithelial cells. During infection, the virus can be isolated from blood, spleen, visceral lymph nodes, and tonsils.